Ascorbic acid
International nonproprietary name
Ascorbic acid
Dosage form
Dragee 50 mg
Compound
One dragee contains
active substance - ascorbic acid - 50 mg
Excipients: sugar (sucrose), starch syrup, sunflower oil, wax, talc, aromatic essence, quinoline yellow
Description
The dragee is greenish-yellow or yellow in color, spherical in shape, uniform in color.
Pharmacotherapeutic group
Vitamins. Ascorbic acid
ATX code A11GA01
Pharmacological properties
Pharmacokinetics
Absorption of ascorbic acid in the oral cavity occurs passively, and in the small intestine - actively with the participation of glucose. Pathology of the gastrointestinal tract (peptic ulcers, constipation, diarrhea, helminthic infestation,
giardiasis) disrupts its absorption from the intestines. When using vitamin C in a therapeutic dose, bioabsorption is 70%; with increasing intake, it decreases. The maximum concentration in the blood is after 4 hours. From the blood, ascorbic acid penetrates best into leukocytes and platelets; it accumulates in the posterior lobe of the pituitary gland, adrenal glands, ocular epithelium and liver.
The biotransformation of ascorbic acid into dehydroascorbic and diketogulonic acid, followed by conversion to oxalic acid, occurs in the liver.
Excretion of all of the above metabolites and ascorbic acid itself in unchanged form is carried out mainly by the kidneys.
Pharmacodynamics
Ascorbic acid is actively involved in many redox reactions and has a nonspecific general stimulating effect on the body. Increases the body's adaptive abilities and its resistance to infections; promotes regeneration processes.
Due to the presence of the dienol group (-COH=COH-) in the molecule, it has strong reducing (antioxidant) properties. Regulates hydrogen transport in many biochemical reactions, improves the use of glucose in the tricarboxylic acid cycle, and participates in the synthesis of tetrahydrofolic acid, steroid hormones, collagen and procollagen.
Participates in cholesterol metabolism, enhances the detoxification and protein-synthesizing function of the liver. Helps maintain the colloidal state of the intercellular substance and normal capillary permeability. Improves bile secretion and exocrine function of the pancreas.
The human body cannot synthesize vitamin C on its own; the need for it is satisfied by containing it in food.
The daily requirement for ascorbic acid in adult men is 0.07-0.1 g, in women - 0.08 g, in pregnant women - 0.1 g, when breastfeeding - 0.12 g.
Indications for use
Prevention, treatment of hypo- and avitaminosis of vitamin C
Hemorrhagic diathesis
Nasal, uterine, pulmonary bleeding
Intoxication
Unbalanced diet
Infectious diseases
Increased physical and mental stress
Liver diseases
Pregnancy and breastfeeding period
The period of recovery after serious long-term illnesses.
Directions for use and doses
The drug is taken orally after meals.
For prevention: adults 0.05-0.1 g (1 - 2 tablets) per day.
For treatment: adults: 0.05-0.1 g (1 - 2 tablets) 3 - 5 times a day.
During pregnancy and breastfeeding, 0.3 g (6 tablets) per day for 10 - 15 days, then prophylactically 0.1 g (2 tablets) per day.
The duration of treatment depends on the nature and course of the disease and is prescribed by a doctor.
Side effects
Headache, feeling tired
With long-term use of large doses - increased excitability of the central nervous system, sleep disturbance
Irritation of the gastrointestinal mucosa, nausea, vomiting, diarrhea, stomach cramps
Moderate pollykiuria, with long-term use - large doses of hyperoxaluria, nephrolithiasis, damage to the glomerular apparatus of the kidneys
With long-term use of large doses - a decrease in capillary permeability
Inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glycosuria)
Skin rash, rarely - anaphylactic shock.
Laboratory indicators:
Thrombocytosis
Hyperprothrombinemia
Erythropenia
Neutrophilic leukocytosis
Hypokalemia
Contraindications
Hypersensitivity to the components of the drug
Thrombophlebitis
Tendency to thrombosis
Diabetes
Increased blood clotting
Children and teenagers up to 18 years of age
Hyperoxalaturia
Kidney failure
Hemochromatosis
Thalassemia
Glucose-6-phosphate dehydrogenase deficiency
Progressive malignant diseases.
Carefully
Polycythemia
Leukemia
Sideroblastic anemia
Sickle cell anemia
Drug interactions
Increases the concentration of benzylpenicillin and tetracyclines in the blood; at a dose of 1 g/day. increases the bioavailability of ethinyl estradiol.
Improves the absorption of iron preparations in the intestines (converts ferric iron to divalent iron); may increase iron excretion when used concomitantly with deferoxamine.
Acetylsalicylic acid (ASA), oral contraceptives, fresh juices and alkaline drinks reduce absorption and absorption.
When used simultaneously with ASA, the urinary excretion of ascorbic acid increases and the excretion of ASA decreases. ASA reduces the absorption of ascorbic acid by approximately 30%.
Increases the risk of developing crystalluria during treatment with salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), and reduces the concentration of oral contraceptives in the blood.
Increases the overall clearance of ethanol, which, in turn, reduces the concentration of ascorbic acid in the body.
Quinoline drugs (fluoroquinolones, etc.), calcium chloride, salicylates, and glucocorticosteroids with long-term use deplete ascorbic acid reserves.
When used simultaneously, it reduces the chronotropic effect of isoprenaline.
Long-term use or use in high doses may interfere with the disulfiram-ethanol interaction.
In high doses, it increases the renal excretion of mexiletine.
Barbiturates and primidone increase the excretion of ascorbic acid in the urine.
Reduces the therapeutic effect of antipsychotropic drugs (phenothiazine derivatives), tubular reabsorption of amphetamine and tricyclic antidepressants.
special instructions
Due to the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor renal function and blood pressure.
With long-term use of large doses, inhibition of the function of the pancreatic insular apparatus is possible, so it must be regularly monitored during treatment.
In patients with high iron levels in the body, ascorbic acid should be used in minimal doses.
Prescribing ascorbic acid to patients with rapidly proliferating and intensively metastasizing tumors can aggravate the process.
Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (blood glucose, bilirubin, transaminase activity, LDH).
Pregnancy and lactation
Use with caution during pregnancy, since high doses of vitamin C more than 1 g per day can cause abortion due to increased estrogen synthesis. Use during pregnancy and lactation after consultation with a doctor.
The minimum daily requirement for ascorbic acid in the II-III trimesters of pregnancy is about 60 mg.
The minimum daily requirement during breastfeeding is 80 mg. A mother's diet containing adequate amounts of ascorbic acid is sufficient to prevent vitamin C deficiency in an infant (it is recommended that a nursing mother not exceed the maximum daily requirement for ascorbic acid).
Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms
Does not affect
Overdose
Symptoms: with long-term use, even in therapeutic doses, heartburn, diarrhea, difficulty urinating or red coloration of urine, hemolysis (in patients with glucose-6-phosphate dehydrogenase deficiency) are possible.
Vitamins. Ascorbic acid (vitamin C). ATX code A11G A01.
Pharmacological properties
Pharmacodynamics
Ascorbic acid (vitamin C) belongs to the group of water-soluble vitamins. Ascorbic acid (vitamin C) has pronounced restorative properties. Takes part in redox reactions, regulation of carbohydrate metabolism, affects the metabolism of aromatic amino acids, the metabolism of thyroxine, the biosynthesis of catecholamines, steroid hormones and insulin, is necessary for blood clotting, the synthesis of collagen and procollagen, the regeneration of connective and bone tissue. Improves capillary permeability. Promotes the absorption of iron in the intestines and takes part in the synthesis of hemoglobin. Increases the body's nonspecific resistance and has antidote properties. A deficiency of vitamin C in food leads to the development of hypo- and avitaminosis C, since this vitamin is not synthesized in the body.
Pharmacokinetics
Suction. Absorbed into gastrointestinal tract(Gastrointestinal tract) (mainly in the jejunum). With an increase in dose to 200 mg, up to 70% is absorbed; with a further increase in dose, absorption decreases to 50-20%. Gastrointestinal diseases (peptic ulcer of the stomach and duodenum, constipation or diarrhea, helminthic infestation, giardiasis), consumption of fresh fruit and vegetable juices, alkaline drinks reduce the absorption of ascorbic acid in the intestines.
The normal concentration of ascorbic acid in plasma is approximately 10-20 μg/ml, body reserves are about 1.5 g when taking daily recommended doses and 2.5 g when taking 200 mg/day. Time to reach maximum concentration (Tcmax) after oral administration is 4 hours.
Distribution. Communication with plasma proteins - 25%. Easily penetrates into leukocytes, platelets, and then into all tissues; the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye; penetrates the placenta. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and plasma. In deficiency states, leukocyte concentrations decline later and more slowly and are considered a better measure of deficiency than plasma concentrations.
Metabolism. Metabolized primarily in the liver into deoxyascorbic acid and further into oxoacetic acid and ascorbate-2-sulfate.
Removal. It is excreted by the kidneys, through the intestines, with sweat, breast milk unchanged and in the form of metabolites.
When high doses are prescribed, the rate of elimination increases sharply. Smoking and drinking ethanol accelerate the destruction of ascorbic acid (conversion into inactive metabolites), sharply reducing reserves in the body. Excreted during hemodialysis.
Indications
Prevention and treatment of vitamin C deficiency.
Conditions of increased need for ascorbic acid: period of intensive growth, unbalanced nutrition, increased mental and physical exercise, the period of convalescence after serious illnesses, febrile conditions against the background of acute respiratory diseases, acute respiratory viral infections, long-term chronic infections.
Contraindications
Hypersensitivity to ascorbic acid or to any of the excipients of the drug. Thrombosis, tendency to thrombosis, thrombophlebitis, diabetes, severe kidney disease. Urolithiasis - when using doses above 1 g per day. Fructose intolerance, glucose-galactose malabsorption syndrome. Children under 6 years old.
Drug interactions
Ascorbic acid, when administered orally, increases the absorption of penicillin, tetracycline, and iron; promotes the absorption of aluminum in the intestine, which should be taken into account during simultaneous treatment with antacids containing aluminum.
The simultaneous use of vitamin C and deferoxamine increases tissue toxicity of iron, especially in the heart muscle, which can lead to decompensation of the circulatory system. Vitamin C can only be used 2 hours after the deferoxamine injection.
Long-term use of large doses by persons treated with disulfiramine inhibits the disulfiram-alcohol reaction.
High doses of the drug reduce the effectiveness of tricyclic antidepressants, neuroleptics - phenothiazine derivatives, tubular reabsorption of amphetamine, interfere with the excretion of mexiletine by the kidneys, and affect the resorption of vitamin B12.
Ascorbic acid increases the overall clearance of ethyl alcohol.
The drug reduces the toxicity of sulfonamide drugs, reduces the effectiveness of heparin and indirect anticoagulants.
Vitamin C increases the excretion of oxalates in the urine, thus increasing the risk of formation of oxalate stones in the urine, and increases the risk of developing crystalluria during treatment with salicylates.
Quinoline drugs, calcium chloride, salicylates, and corticosteroids with long-term use reduce ascorbic acid reserves in the body.
Absorption of ascorbic acid is reduced with simultaneous use of oral contraceptives, consumption of fruit or vegetable juices, and alkaline drinking.
If you are taking any other medications, consult your doctor about the use of the drug.
Features of application
Before starting treatment, consult your doctor!
When using high doses or long-term use of the drug, it is necessary to monitor kidney function and blood pressure levels, as well as pancreatic function. Should be used with caution medicine patients with a history of kidney disease.
For urolithiasis, the daily dose of ascorbic acid should not exceed 1 g. Large doses of the drug should not be prescribed to patients with increased blood clotting.
Because ascorbic acid increases iron absorption, its use in high doses may be harmful to patients with hemochromatosis, thalassemia, polycythemia, leukemia and sideroblastic anemia. Patients with high iron content in the body should use the drug in minimal doses.
Simultaneous use of the drug with an alkaline drink reduces the absorption of ascorbic acid, so you should not drink it with an alkaline drink. mineral water. Also, the absorption of ascorbic acid may be impaired by intestinal dyskinesia, enteritis and achylia.
Use with caution to treat patients with glucose-6-phosphate dehydrogenase deficiency.
Ascorbic acid as a reducing agent can affect the results laboratory research, for example, when determining blood glucose, bilirubin, transaminase activity, lactate dehydrogenase.
Since ascorbic acid has a mild stimulating effect, it is not recommended to use the drug at the end of the day. Due to the stimulating effect of ascorbic acid on the formation of corticosteroid hormones, when using the drug in large doses, monitoring of kidney function and blood pressure is necessary.
Use during pregnancy or breastfeeding
A lack of vitamin C in the diet of pregnant women can be dangerous for the fetus, however, its use in large doses can also negatively affect the development of the fetus, therefore during pregnancy the drug is used only in accordance with dosing recommendations and doctor's prescription.
Ascorbic acid penetrates into breast milk Therefore, during breastfeeding, vitamin C should be taken under the supervision of a doctor, in compliance with the recommended doses.
The ability to influence the reaction rate when driving vehicles or other mechanisms
Does not affect.
Use in children
The drug should be used in children over 6 years of age.
Directions for use and doses
The medicine should be taken orally after meals.
For prevention purposes, adults and children over 14 years of age should take 2-4 tablets (50-100 mg) per day; children aged 6 to 14 years - 1-2 tablets (50 mg) per day.
Therapeutic doses for children aged 14 years and adults are 2-4 tablets (50-100 mg) 3-5 times a day, for children from 6 to 10 years - 4 tablets (100 mg) 2-3 times a day. daily, children aged 10 to 14 years - 4-6 tablets (100-150 mg) 2-3 times a day.
The dosage and course of treatment depend on the nature and characteristics of the disease and are determined by the doctor.
Overdose
Ascorbic acid is well tolerated. It is a water-soluble vitamin and excess amounts are excreted in the urine.
Symptoms. With long-term use of vitamin C in large doses, the function of the insular apparatus of the pancreas may be inhibited, which requires monitoring the condition of the latter. Overdose may result in altered renal excretion of ascorbic and uric acids during urine acetylation with the risk of precipitation of oxalate stones.
The use of large doses of the drug may lead to vomiting, nausea or diarrhea, which disappear after its discontinuation.
Treatment. Symptomatic therapy.
Ascorbic acid (vitamin C) is not formed in the human body, but comes only from food.
Pharmacological effects: in quantities significantly exceeding the daily requirement (90 mg), it has almost no effect, with the exception of the rapid elimination of symptoms of hypo- and vitamin deficiency (scurvy).
Physiological functions: is a cofactor in some hydroxylation and amidation reactions - transfers electrons to enzymes, providing them with a reducing equivalent. Participates in the reactions of hydroxylation of proline and lysine residues of procollagen with the formation of hydroxyproline and hydroxylysine (post-translational modification of collagen), oxidation of lysine side chains in proteins with the formation of hydroxytrimethyllysine (in the process of cartinitis synthesis), oxidation of folic acid to folinic acid, drug metabolism in liver microsomes and hydroxylation dopamine to form norepinephrine.
Increases the activity of amidating enzymes involved in the processing of oxytocin, antidiuretic hormone and cholecystokinin. Participates in steroidogenesis in the adrenal glands;
Restores Fe3+ to Fe2+ in the intestine, promoting its absorption. The main role in tissues is participation in the synthesis of collagen, proteoglycans and other organic components of the intercellular substance of teeth, bones and capillary endothelium.
In low doses (150-250 mg/day orally) it improves the complexing function of deferoxamine in chronic intoxication with iron preparations, which leads to increased excretion of the latter.
Ascorbic acid is actively involved in many redox reactions and has a nonspecific general stimulating effect on the body. Increases the body's adaptive abilities and its resistance to infections; promotes regeneration processes.
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Ascorbic acid tablets instructions
Ascorbic acid dosage
Ascorbic acid is prescribed in the following doses:
Preventive
- children – 25 mg per day;
- adults – 50-100 mg per day;
Therapeutic
- children – 50-100 mg per day;
- adults – 150-200 mg per day;
- pregnant and nursing mothers – 250-300 mg per day.
Ascorbic acid tablets composition
1 tablet contains 50 mg of ascorbic acid calculated as pure substance.
Additional components: sugar, molasses, talc, yellow wax, orange flavoring, mineral oil, dye E 104.
Release form
Available in the form of spherical dragees, yellow in color, with a uniformly colored surface.
Vitamin C preparations
Ascorbic acid tablets - pharmacological action
Ascorbic acid is a powerful antioxidant. Protects cell walls from the destructive effects of free radicals by controlling redox reactions. Ascorbic acid affects the following body systems:
Immune.
- stimulation of immunity;
- increasing the body's resistance to infectious diseases;
- reducing the manifestations of inflammation and allergies;
- participation in the restoration of antioxidants - vitamins A and E.
Endocrine.
- stimulation of hormone synthesis;
- increased excretory activity of the pancreas;
- stimulation of hormonal activity of the thyroid gland.
Digestive.
- stimulation of the synthesis of building proteins in the liver;
- participation in the formation of digestive enzymes;
- increased antitoxic activity of the liver;
- stimulation of bile secretion.
Cardiovascular and circulatory systems.
- increasing the bioavailability of iron necessary for the formation of hemoglobin;
- reducing the level of “bad” cholesterol in the blood;
- increased blood clotting;
- normalization of the permeability of small vessels.
Indications for use
Ascorbic acid in tablets is indicated for use in the following cases:
Indications
- hypo- and vitamin deficiency C;
- period of intensive growth;
- monotonous and unbalanced diet;
- hard mental and physical work;
- recovery period after illnesses and operations;
- alcohol, nicotine and drug addiction;
- stress and depression;
- pregnancy and breastfeeding;
- iron poisoning;
- anemia;
- hemorrhagic diathesis;
- bleeding disorders;
- infectious diseases;
- systemic intoxication;
- poorly healing wounds and fractures.
Contraindications
Taking ascorbic acid in tablets is contraindicated in the following cases:
- thrombophlebitis;
- predisposition to blood clots;
- diabetes;
- hypersensitivity to the components of the drug;
- acute renal failure;
- exacerbation of urolithiasis;
- fructose intolerance.
Side effects
In rare cases, taking ascorbic acid in tablets can cause allergic reactions. The following symptoms may be observed in individual body systems:
- headache;
- weakness and oppression;
- insomnia;
- excessive excitability.
Digestive.
- nausea and vomiting;
- diarrhea;
- inflammation of the mucous membrane of the stomach and intestines;
- painful cramps in the abdomen.
Endocrine.
- decreased endocrine function of the pancreas;
- increased blood sugar levels.
Cardiovascular and circulatory system.
- blood clot formation;
- increased blood pressure;
- myocardial dystrophy.
Laboratory parameters may change - the content of platelets, prothrombin, sodium and neutrophil leukocytes in the blood will increase, and the number of red blood cells and potassium will decrease.
How to take ascorbic acid in tablets - special instructions
Ascorbic acid stimulates the adrenal cortex, so blood pressure and kidney condition should be monitored while taking it.
With a long course, you need to monitor the endocrine function of the pancreas. If there is a high iron content in the blood, ascorbic acid is prescribed in minimal dosages.
In patients with fast-growing tumors, the drug can accelerate the pathological process. Taking ascorbic acid distorts the results of laboratory tests.
Ascorbic acid - instructions for interaction with other drugs
When using ascorbic acid in tablets simultaneously with other drugs, the following may occur:
- increased blood concentrations of penicillin and tetracycline antibiotics;
- decreased effectiveness of drugs that reduce blood clotting;
- decreased bioavailability of ascorbic acid when taking oral contraceptives and alkaline solutions;
- sulfonamides and salicylic acid increase the risk of crystals in the urine;
- glucocorticosteroids and calcium preparations reduce the content of ascorbic acid in the body;
- The effectiveness of antidepressants decreases.
Ascorbic acid tablets instructions for use
Ascorbic acid is taken orally after meals in doses prescribed by the doctor. For children, the tablets can be dissolved in water and given as a drink.
Overdose
In case of an overdose of ascorbic acid, the following is observed:
- abdominal pain;
- nausea;
- vomit;
- diarrhea;
- bloating;
- rash;
- overexcitability nervous system;
Taking large doses over a long period of time can cause a decrease in insulin production and the formation of bladder stones. In case of overdose, it is necessary to rinse the stomach, take sorbents and immediately consult a doctor.
Terms of sale
Sold in pharmacies without a prescription.
Storage conditions
Store in original packaging, in a dark place, out of reach of children, at a temperature not exceeding 25°C.
Best before date
Shelf life: 18 months.
Reviews
The vast majority of consumer reviews confirm the appearance of the indicated pharmacological action after a course of treatment with ascorbic acid in tablets. The frequency of side effects coincides with the data stated in the instructions.
kalorizator.com
Ascorbic acid: instructions for the use of vitamin C in tablets, indications, dosage
What is the composition of ascorbic acid and in what form is it produced. In what cases is it prescribed and how to choose the dosage.
Ascorbic acid (vitamin C) is a substance that the body needs to form collagen, strengthen the structure of bone tissue, capillaries and teeth. The element is involved in the metabolism of tyrosine, redox reactions, the breakdown of carbohydrates, and the production of proteins and lipids.
Also, ascorbic acid is an essential element of cellular respiration. It reduces the need for tocopherol, retinol, vitamins B1 and B2, pantothenic and folic acid. The action of vitamin C is aimed at strengthening the immune system, absorbing iron and performing antioxidant functions. Below are the subtleties of taking and dosing ascorbic acid, instructions for using the drug in the form of dragees (50 mg).
Composition and forms
Today ascorbic acid is available in the form of:
- Tablets - 25 and 50 mg (glucose is added to some drugs).
- Dragee - 50 mg.
- Oral solution - 2.5 g.
- Solution for injection (intramuscular and intravenous).
The most popular form of vitamin C is pills, which contain:
- Ascorbic acid - 0.05 grams;
- Additional elements are wheat flour, starch syrup, sugar and sunflower oil. Beeswax, fragrances, talc and dyes are also added.
The composition of auxiliary elements may vary - much depends on the manufacturer of the drug.
Pharmacokinetics
Ascorbic acid (vitamin C) is a substance that has a multifaceted effect on the human body:
- Improving blood clotting.
- Restoration of body cells.
- Participation in oxidative and reduction reactions.
- Regulation of amino acid and carbohydrate metabolism.
- Helps in the biosynthesis of catecholamines and carbohydrate metabolism.
- Biosynthesis of insulin and steroid hormones.
- Production of procollagen and collagen.
- Regeneration of bone and connective tissue.
- Absorption of iron from food.
- Hemoglobin production and normalization of blood composition.
- Improving capillary permeability, which reduces the risk of developing cardiovascular diseases.
- Increased nonspecific resistance of the body.
- Antioxidant properties.
A lack of ascorbic acid leads to the development of vitamin C deficiency due to the body’s inability to synthesize this vitamin on its own.
After consuming vitamin C tablets, it passes into the small intestine, where ascorbic acid is absorbed. A deterioration in the absorption process of a substance is possible in the following cases:
- intestinal dyskinesia;
- ahilia;
- enteritis;
- giardiasis;
- helminthic infestation;
- drinking alkaline drinks;
- taking fruits and fresh vegetable juices.
The highest concentration of the drug is achieved four hours after administration. The peculiarity of the substance is its rapid penetration into platelets, leukocytes, and then into all tissues human body. The substance then accumulates in the following parts of the body:
- posterior part of the pituitary gland;
- ocular epithelia;
- liver;
- ovaries;
- intestinal walls;
- adrenal cortex;
- intermediate cells of the seminal glands;
- spleen;
- pancreas and thyroid gland;
- heart and muscles.
The substance is metabolized primarily in the liver, converted into deoxyascorbic acid, and then into dikeocarbonic and oxaloacetic acids. Excess products (metabolites and ascorbate) are excreted along with urine and feces.
Part of vitamin C passes into mother's breast milk, which should be taken into account during feeding. In the case of taking the supplement in an increased dosage, when the concentration increases to a level of 1.4 mg / deciliter or more, the excretion of the drug also increases. At the same time, accelerated withdrawal often persists even after taking the supplement.
Indications for use
Vitamin C tablets are prescribed in the following cases:
- Treatment or prevention of vitamin C deficiency (hypo- and vitamin deficiency).
- Excessive stress (mental and physical).
- A condition when the body needs an increased amount of ascorbic acid.
- Diets or poor nutrition.
- Periods of active growth.
- As a component of complex treatment of alcoholism.
- Long-term chronic infections.
- Chronic intoxication with iron-containing drugs. The need for vitamin C often arises during complex therapy with deforoxamine.
- Nicotine addiction.
- Burn diseases.
- Idiopathic methemoglobinemia.
- Pregnancy, postoperative period.
- Excessive stress related to work or home troubles. It is possible to prescribe ascorbic acid for disorders of the central nervous system.
- Feverish conditions manifesting themselves against the background of long-term respiratory diseases, as well as viral infections.
Dosage
Despite the free sale and safety of the drug, it is important to know how to take vitamin C tablets and strictly follow the recommended dosage. Administration is carried out orally, after eating food. The dosage is as follows:
- For prevention:
- Adults - 50-100 mg per day (1-2 tablets).
- Children over the age of five - 50 mg per day (1 tablet).
- For medicinal purposes:
- Adults - 50-100 mg (one serving), 3-5 times a day.
- Children aged five years and over - 50-100 mg (1-2 tablets). Frequency of administration: 2-3 times a day.
- Pregnancy and lactation period. For the first 1.5-2 weeks, take 300 mg (6 tablets) per day, after which 100 mg (2 tablets) per day.
The maximum requirement for ascorbic acid in the 2-3 trimester of pregnancy is 50-60 mg. During the feeding period, it is important that the body receives 80-100 mg of vitamin C. This is enough to prevent vitamin C deficiency in a baby during infancy. During lactation, it is important to control the amount of vitamin intake and avoid overdose, despite the lack of evidence of a negative effect on the child.
During pregnancy, ascorbic acid quickly passes through the placental barrier, due to which the fetus quickly adapts to increased dosages. Afterwards, the newborn baby may experience a withdrawal reaction. To avoid problems, the dosage of vitamin C during pregnancy should be strictly controlled.
Overdose and side effects
In case of prolonged use of the drug in a dosage exceeding 1 gram per day, the following problems are possible:
- diarrhea;
- heartburn;
- difficulty urinating;
- red coloring of urine;
- hemolysis.
Treatment of overdose is carried out taking into account the current symptoms. First of all, it is recommended to stop taking the drug and also limit the consumption of foods that contain vitamin C.
The following side effects are possible during administration:
- Malfunctions of the central nervous system:
- feeling tired;
- headache;
- sleep disturbance;
- excitability of the central nervous system.
- Disorders of the urinary system:
- hyperoxalaturia;
- formation of calcium oxalate;
- formation of urinary stones.
- Digestive system problems:
- vomit;
- nausea;
- irritation of the gastrointestinal mucosa;
- stomach cramps;
- diarrhea.
- Allergic manifestations:
- skin rash;
- anaphylactic shock.
- Malfunctions of the endocrine system (associated with disruption of the insular apparatus):
- hyperglycemia;
- glucosoria.
- Disorders of the cardiovascular system:
- myocardial dystrophy;
- microangiopathy;
- increased blood pressure;
- thrombosis.
- Changes in laboratory parameters:
- erythropenia;
- hyperprothrombinemia;
- thrombocytosis;
- hypokalemia;
- neutrophilic leukocytosis.
- Other problems:
- increased body temperature;
- sodium retention;
- disturbance of zinc and copper metabolism;
- hypovitaminosis;
- fluid retention in cells.
- anemia;
- renal failure;
- hyperoxalaturia;
- thalassemia;
- hemochromatosis;
- leukemia;
- sideroblastic or sickle cell anemia;
- malignant diseases;
- lack of glucose-6-phosphate dehydrogenase.
Interaction with other drugs
During the period of taking ascorbic acid, the nuances of the interaction of the vitamin with other substances (drugs) should be taken into account. The following action is worth highlighting here:
- Improving the absorption of iron in the intestines, as well as accelerating the excretion of metal when combined with Deferoxamine.
- Increased risk of crystalluria during treatment with sulfonamides and salicylates. At the same time, the process of excretion of acids through the kidneys slows down, and the rate of elimination of drugs that have an alkaline reaction increases. In addition, the concentration of oral contraceptives in the blood decreases.
- Depletion of vitamin C reserves in case of taking salicylates, calcium chloride, as well as the quinoline series.
- Increasing the total clearance of ethanol, which reduces the level of ascorbic acid in the blood and living tissues.
- Reduced absorption and deterioration of digestibility when combining vitamin C with acetylsalicylic acid, alkaline drinking, or oral contraceptives.
- Increased volume of tetracyclines and benzylpenicillin in the blood. Also, when the dosage is increased above one gram per day, the bioavailability of ethinyl estradiol increases.
- Increased renal excretion of Mexiletine (in case of taking ascorbic acid in high dosages).
- Acceleration of the excretion of vitamin C in the urine when taking Primidone and barbiturates.
- Reduced chronotropic effect of isoprenaline (with simultaneous use).
- Deterioration of the therapeutic effect of tricyclic antidepressants, tubular reabsorption of amphetamine, decreased effect of antipsychotics.
special instructions
For vitamin C, the instructions for using the pills stipulate a number of special instructions that should be followed during the course:
- Ascorbic acid should be taken with caution in case of impaired renal function, hyperoxaluria, or if there are indications of urolithiasis.
- Due to increased iron absorption, taking vitamin C in large doses is dangerous for people with polycythemia, thalassemia, leukemia and sideroblastic anemia. People with high iron levels in the body are advised to limit their intake of ascorbic acid.
- In case of increased intake, the condition may worsen in the presence of sickle cell anemia.
- There is a high risk of exacerbation if the patient has disseminated or proliferating tumors, which can only aggravate the process.
- Diabetics are advised to keep glucose levels in the body under control while taking the drug.
- When drinking vegetable or fruit juices, as well as alkaline drinks, vitamin C is absorbed and absorbed less well.
- Due to the stimulating effect of the substance on the production of corticosteroid hormones, it is recommended to monitor kidney function and periodically measure blood pressure.
- During the period of taking ascorbic acid, the readings of many laboratory tests may be distorted.
Analogs
The pharmaceutical sector offers a wide selection of drugs containing vitamin C. They all differ in the volume of active substance, manufacturer, set of auxiliary elements and pricing policy. The most well-known drugs include:
- Cevicap.
- Celascon.
- Multi-Tabs with vitamin C.
- Ascovit.
- Additiva Vitamin C.
- Set you 500.
- Plivit S.
- Celaxon Effervescens.
- Vitamin C PLUS Kid formula Farmamed and others.
Shelf life and storage conditions
Ascorbic acid in the form of dragees has a shelf life of 1.5 years. The drug should be stored in a dry and dark place. Storage temperature - up to +25 degrees Celsius.
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Ascorbic acid tablets: instructions for use
Active ingredient: ascorbic acid;
1 dragee contains ascorbic acid - 50 mg;
excipients: starch syrup, white sugar, yellow wax, mineral oil, talc, orange flavor (contains propylene glycol).
Description
international generic name: ascorbic acid;
basic physicochemical characteristics: dragee white or white with a yellowish tint. In appearance they should have spherical shape.
pharmachologic effect
Ascorbic acid (vitamin C) has pronounced restorative properties. Belongs to the group of water-soluble vitamins. Participates in redox reactions, regulation of carbohydrate metabolism, affects the metabolism of aromatic amino acids, thyroxine metabolism, biosynthesis of catecholamines, steroid hormones and insulin, is necessary for blood clotting, collagen and procollagen synthesis, regeneration of connective and bone tissue. Improves capillary penetration. Promotes the absorption of iron in the intestines and takes part in the synthesis of hemoglobin. Increases the body's nonspecific resistance and has antidote properties. A deficiency of vitamin C in food leads to the development of hypo- and avitaminosis C, since this vitamin is not synthesized in the body.
Absorption of ascorbic acid occurs primarily in the small intestine. The absorption process can be disrupted by intestinal dyskinesia, enteritis, achylia, helminthic infestation, giardiasis, as well as by consuming alkaline drinks, fresh fruits and vegetable juices. The maximum concentration of the drug in plasma after oral administration is achieved after 4 hours. Easily penetrates into leukocytes, platelets, and then into all tissues; deposited in the posterior part of the pituitary gland, adrenal cortex, ocular epithelium, intermediate cells of the seminal glands, ovaries, liver, brain, spleen, pancreas, lungs, kidneys, intestinal wall, heart, muscles, thyroid gland. Metabolized primarily in the liver into deoxyascorbic acid and further into oxaloacetic and diketogulonic acids. Unchanged ascorbate and metabolites are excreted in urine, feces and excreted in breast milk. When high doses are used, when plasma concentrations reach above 1.4 mg/dL, excretion increases sharply, and increased excretion may persist after discontinuation of use.
Indications for use
Prevention and treatment of vitamin C deficiency in the body.
Prevention and treatment of scurvy, stimulation of tissue regeneration, in complex therapy of bleeding (uterine, pulmonary, nasal), with radiation sickness syndrome, bone fractures, hemorrhagic diathesis, intoxication and infections, Addison's disease with an overdose of anticoagulants, during pregnancy and lactation, with increased mental stress and physical overload.
Contraindications
Hypersensitivity to ascorbic acid or to the excipient of the drug. Thrombosis, tendency to thrombosis, thrombophlebitis, diabetes mellitus, severe kidney disease. Urolithiasis - when using doses above 1 g per day. Fructose intolerance, glucose-galactose malabsorption syndrome.
Children's age up to 4 years.
Pregnancy and lactation
A lack of vitamin C in the diet of pregnant women can be dangerous for the fetus, however, its use in high doses can also negatively affect the development of the fetus, therefore, during pregnancy, ascorbic acid is used exclusively as directed and under the supervision of a doctor, strictly adhering to the recommended doses (see section " Directions for use and dosage").
Ascorbic acid passes into breast milk, so during breastfeeding, vitamin C should be taken under the supervision of a doctor, adhering to the recommended doses (see section “Method of administration and dosage”).
Directions for use and doses
Prescribed to adults and children over 4 years of age. Dragees are taken orally after meals. The therapeutic dose for adults and children over 14 years of age is 50-100 mg (1-2 tablets) 3-5 times a day.
children aged 4-7 years - 50-100 mg (1-2 tablets), children aged 7-10 years - 100 mg (2 tablets),
children aged 11-14 years - 100-150 mg (2-3 tablets) 2-3 times a day.
For preventive purposes, ascorbic acid is prescribed to adults and children over the age of 14 years in a daily dose of 50-100 mg (1-2 tablets).
For the purpose of preventing hypovitaminosis, children aged 4-14 years are prescribed 50 mg (1 tablet) 1 time per day.
Pregnant women, women after childbirth, as well as with low levels of vitamin C in breast milk are prescribed a daily dose of 300 mg (6 tablets) for 10-15 days, after which (for preventive purposes throughout the entire period of breastfeeding) - in a daily dose 100 mg (2 tablets).
The duration of use is determined by the doctor depending on the nature of the pathological condition and the effectiveness of therapy.
Side effect
Ascorbic acid is generally well tolerated, but some problems may occur. adverse reactions:
from the digestive tract: when used in a dose of more than 1 g per day - irritation of the mucous membrane of the digestive tract, heartburn, nausea, vomiting, diarrhea; from the urinary system: damage to the glomerular apparatus of the kidneys, crystalluria, formation of urate, cystine and/or oxalate stones in the kidneys and urinary tract;
allergic reactions: skin rash, Quincke's edema, urticaria; sometimes - anaphylactic shock in the presence of sensitization;
from the endocrine system: damage to the insular apparatus of the pancreas (hyperglycemia, glucosuria) and impaired glycogen synthesis, leading to the onset of diabetes mellitus;
from the cardiovascular system: arterial hypertension, myocardial dystrophy; from the side of the hematopoietic system: thrombocytosis, hyperprothrombinemia, erythrocytopenia, neutrophilic leukemia; in patients with deficiency of glucose-6-phosphate dehydrogenase of blood cells, hemolysis of red blood cells may result;
from the nervous system: increased excitability, sleep disturbance, headache; on the metabolic side: metabolic disorders of zinc and copper.
If any undesirable reactions occur, consult your doctor regarding further use of the drug!
Overdose
Symptoms: with a single use of excessive doses of the drug, it is possible
the occurrence of nausea, vomiting, bloating and abdominal pain, itching, skin rash, increased excitability.
With long-term use in high doses, it is possible to suppress the insular apparatus of the pancreas (its function must be monitored), develop cystitis, and accelerate the formation of stones (urates, oxalates).
Treatment: discontinuation of the drug, gastric lavage, alkaline drinking, taking activated carbon or other sorbents, symptomatic therapy.
Interaction with other drugs
If you are taking any other medications, be sure to tell your doctor!
Absorption of ascorbic acid is reduced with simultaneous use of oral contraceptives, consumption of fruit or vegetable juices, and alkaline drinking. Ascorbic acid, when administered orally, increases the absorption of penicillin, tetracycline, iron, reduces the effectiveness of heparin and indirect anticoagulants, and increases the risk of developing crystalluria when treated with salicylates. Concomitant use of vitamin C and deferoxamine increases tissue toxicity of iron, especially in the heart muscle, which can lead to decompensation of the circulatory system. Vitamin C can only be taken 2 hours after the deferoxamine injection.
Long-term use of large doses by persons treated with disulfiramine inhibits the disulfiram-alcohol reaction. Large doses of the drug reduce the effectiveness of tricyclic antidepressants, neuroleptics - phenothiazine derivatives, tubular reabsorption of amphetamine, and interfere with the excretion of mexiletine by the kidneys.
Ascorbic acid increases the total clearance of ethyl alcohol. Quinoline drugs, calcium chloride, salicylates, and corticosteroids, when used for a long time, reduce the reserves of ascorbic acid in the body.
Features of application
The ability to influence the reaction rate when driving a vehicle or working with other mechanisms. Does not affect.
Children. The drug is prescribed to children over 4 years of age.
Precautionary measures
Before starting treatment, consult your doctor!
When using the drug, you must adhere to the doses recommended by your doctor!
When taking high doses and long-term use of the drug, it is necessary to monitor kidney function and blood pressure levels, as well as pancreatic function. It should be used with caution in patients with a history of kidney disease.
For urolithiasis, the daily dose of ascorbic acid should not exceed 1 g.
You should not prescribe large doses of the drug to patients with increased blood clotting.
Since ascorbic acid increases the absorption of iron, its use in high doses may be dangerous for patients with hemochromatosis, thalassemia, polycythemia, leukemia and sideroblastic anemia. Patients with high iron content in the body should use the drug in minimal doses.
Simultaneous use with an alkaline drink reduces the absorption of ascorbic acid, so you should not drink the pills with alkaline mineral water. Also, the absorption of ascorbic acid may be impaired by intestinal dyskinesia, enteritis and achylia. Use with caution to treat patients with glucose-6-deficiency
phosphate dehydrogenase.
Ascorbic acid as a reducing agent can affect the results of laboratory tests, for example, when determining blood glucose, bilirubin, transaminase activity, lactate dehydrogenase, etc.
Since Ascorbic acid has a slight stimulating effect, it is not recommended to take the medicine at the end of the day.
Release form
50 tablets with a dosage of 50 mg in containers. 1 container in a cardboard pack.
Storage conditions
Store in original packaging at temperatures above 25 °C.
Best before date
1 year 6 months
Conditions for dispensing from pharmacies
Without a doctor's prescription.
Ascorbic acid tablets analogs, synonyms and group preparations
Self-medication may be harmful to your health. You should consult your doctor and also read the instructions before use.
Vitamin C is a biologically active substance necessary for the normal functioning of the body. Found in many foods, but most of all in vegetables and fruits. Pharmacological enterprises produce synthetic vitamins through the fermentation of glucose. The release forms are different: dragees, tablets, powders and injection solution in ampoules.
Vitamin C is a biologically active substance necessary for the normal functioning of the body.
General characteristics composition
Ascorbic acid 50 mg (pellets) is a white, light green or yellowish ball that contains 0.05 g of vitamin C as an active ingredient. Auxiliary components are mineral oil, sugar, molasses, talc, yellow wax, fruit essence and quinoline dye.
Pharmacological properties
Ascorbic acid is a water-soluble vitamin that is essential in redox reactions; affects the metabolism of proteins, lipids, amino acids and carbohydrates, the biosynthesis of collagen, hemoglobin, steroid hormones and insulin. Promotes the regeneration of connective and bone tissues, strengthens the walls of capillaries.
Vitamin C improves iron absorption and promotes its deposition. It has a general stimulating effect, increases the body's ability to adapt and resist infections, reduces intoxication and is a powerful antioxidant.
The vitamin is adsorbed in the small intestine, penetrates into blood elements (leukocytes, platelets and, to a lesser extent, into erythrocytes and plasma), and then into all tissues of the body.
The main route of excretion is in the urine; in addition, the substance is excreted in feces and sweat.
Indications for use of Ascorbic acid in tablets 50 mg
The vitamin preparation is prescribed for prevention and as an adjuvant in the treatment of various conditions:
How to take Ascorbic acid in tablets 50 mg?
The drug should be taken orally after meals with a small amount of water. Doctors do not recommend taking the vitamin shortly before bedtime, as it has a mild stimulating effect.
Preventive daily intake for an adult – 0.05 or 0.1 g; For treatment, 1-2 tablets are prescribed up to 5 times a day.
For severe colds, the dosage is increased 2-3 times (for 5-7 days).
Contraindications
Hypersensitivity to the main active ingredient or additional ingredients of the drug, thrombophlebitis or a tendency to thrombosis. The drug in pill form is not prescribed to children under 5 years of age.
Vitamin C should be used with caution in the treatment of patients with signs of oxalaturia, hereditary hemochromatosis or functional renal disorders, diabetes mellitus, some forms of anemia and progressive tumor diseases.
Side effects of Ascorbic acid in tablets 50 mg
When using the drug, undesirable reactions from various systems may occur:
- CNS – headache, sleep disturbances, increased excitability of the nervous system;
- Gastrointestinal tract - nausea, vomiting, stomach cramps, diarrhea and symptoms of irritation of the digestive tract mucosa;
- urination – formation of oxalate stones (with long courses of treatment);
- cardiovascular system - increased blood pressure, thrombocytosis, erythropenia, neutrophilic leukocytosis, hemolysis (destruction of red blood cells);
- endocrine system - glucosuria or hyperglycemia.
An allergy to the drug manifests itself in the form of skin rash, redness and swelling. In case of hypersensitivity, an anaphylactic reaction is possible in rare cases.
Overdose
Significant excess of the dosage - consumption of more than 1 g per day - can provoke diarrhea, dysuria, change in urine color (from pink to red). In such cases, you should stop taking the vitamin and consult a doctor.
Exceeding the dosage to 20-25 g poses a threat to life (especially for a child).
Use during pregnancy and breastfeeding
Pregnant and lactating women can take medications and biologically active agents only as prescribed by a specialist.
In case of deficiency, the vitamin is prescribed for 1.5-2 weeks, 6 tablets per day, then the dose is reduced to 2 pieces. per day, the duration of the course is determined by the attending physician.
Use in children
For the purpose of prevention and nutritional adjustment, children from 5 years of age are recommended to take 1 tablet (0.05 g) per day. The dosage of the vitamin during treatment can be increased depending on age to 0.15-0.3 g per day.
Ascorbic acid, vitamin C, ascorbic acid is a drug that every person has known since childhood. Ascorbic acid is easy to drink, and the instructions for use are simple and clear. Tablets or dragees have a sweet taste and are used in various cases. They have a general strengthening effect on the body.
Ascorbic acid is available in the form of chewable tablets, solution, dragees, injection ampoules and powder. The dragee contains, as a rule, 50 mg of ascorbic acid. Sold in glass or plastic jars, or contour cells. In one bottle, the number of dragees ranges from 50 to 200 pieces.
The dosage of chewable tablets can vary from 25 mg to 250 mg. They also come in a jar or blister. There are 5 blisters in a cardboard box. You can buy any number of tablets.
If it is a powder, each packet may contain 500 mg. There is also a higher dosage - 1000 mg. Ascorbic acid, produced in liquid form specifically for injections, comes in ampoules of 1 or 2 ml. There are 10 pieces in total in the box.
The active substance is ascorbic acid. There are a number of auxiliary components. The list includes sugar and wheat flour. There is another drug containing vitamin C - “Rutascorbin”. It is a combined medication that also contains rutin.
More information about the composition
The composition of the drug in powder form contains only ascorbic acid. If it is an injection solution, water, sodium bicarbonate, disodium edetate, sulfite and cysteite are also present. The composition of dragees and tablets includes lactose, sugar, talc, dyes and other additional components.
pharmachologic effect
First of all, taking ascorbic acid is aimed at replenishing the lack of vitamin C. Under the influence of the substance, accelerated healing of skin damage occurs. The vitamin has antioxidant and metabolic properties. Takes part in blood clotting.
Improves the functioning of the thyroid gland. Restores the functionality of the pancreas and improves bile secretion. Taking ascorbic acid can increase the body's resistance to various infections.
Pharmacodynamics and pharmacokinetics
Absorption of ascorbic acid after administration occurs in the small intestine. The absorption of substances may be impaired as a result of taking alkaline drinks, vegetable and fruit juices from fresh foods. Vitamin C accumulates inside cells.
Ascorbic acid penetrates first into platelets and leukocytes, then to other tissues of the body. The level of ascorbic acid increases 25 minutes after administration. It is further converted into dehydroascorbic acid.
Excretion from the body occurs along with urine and feces. A small portion is excreted through sweat and breast milk. The rate of elimination may increase if the dose was increased several times during administration.
Indications for use of the drug
Vitamin C is often used as a prophylactic for hypovitaminosis and vitamin deficiency. Ascorbic acid helps stop bleeding different types(renal, pulmonary, nasal and others). Indicated for diseases of an infectious nature.
Restores the body after poisoning, when symptoms of intoxication are noticeable. The treatment regimen includes ascorbic acid for gastrointestinal diseases, including ulcers and colitis.
The vitamin is an integral component during increased mental and physical stress.
Instructions for use of ascorbic acid
The solution enters the human body through intramuscular injection. The dosage per day ranges from 1 to 3 ml of liquid. If the patient is a child - no more than 2 ml. The number of days for treatment is determined by the doctor.
The tablet form is usually used to prevent hypovitaminosis and other diseases. During therapy, pills are prescribed. Children are especially delighted with the tablets during treatment because they are effervescent. The duration of use does not exceed 2 weeks.
To prepare the drink you will need the drug in powder form. Drink only after eating. Warm boiled water is used for dissolution. The dose and course of treatment are determined by the attending physician.
Is it possible to take ascorbic acid during pregnancy and lactation?
The answer to the question is yes. But the dosage should be minimal so that the expectant mother benefits from taking it without harming the baby. In the first 2 weeks, the daily dose is 300 mg. Afterwards it decreases to 100 mg.
Features of use in children
Tablets or dragees are allowed in childhood from 3 years. The dosage is 25 mg. If the child is over 5 years old, you can give 50 mg of the drug. Adolescents are allowed 100 to 150 mg per day.
Vitamin C should not be given to children at an early age, as they are unable to swallow the drug. It is important to ensure that the baby does not choke on the medicine. In any case, you need to consult a doctor.
After the examination, the specialist may prescribe ascorbic acid in the form of injections. The dose does not exceed 2 mg per day. The injection is given in the evening before bedtime.
Drug overdose
If you take high doses of vitamin C, you may experience pain in the abdominal area. Most often, patients experience nausea. An overdose is also accompanied by vomiting, digestive disorders, and diarrhea. The skin suffers, as it becomes covered in a rash and itches.
It is not recommended to take ascorbic acid for a long time, especially in high doses. This promotes the formation of kidney stones. If symptoms of overdose are observed, the patient is given symptomatic treatment.
Contraindications for use
The drug should not be taken if you have kidney problems, including urolithiasis. Ascorbic acid is not prescribed to children under 3 years of age. Contraindications are also diabetes mellitus and the body's sensitivity to the components of the medicine.
Side effects of the drug
If you use the doses prescribed by your doctor, ascorbic acid is easily tolerated by the body. But development is possible side effect. The negative effects of vitamin C can be seen in headaches, swelling of the skin and increased blood pressure. Medicine in the form of powder, dragees or tablets can irritate the mucous membranes of the stomach, resulting in heartburn, nausea and vomiting.
Special instructions for the drug
A long course of ascorbic acid therapy affects the condition of the pancreas. The function of the insular apparatus is inhibited. To prevent this from causing a deterioration in a person’s condition, it is necessary to monitor the organ. If the patient has high level iron in the blood, it is recommended to take vitamin C in minimal doses.
Interaction with other substances
Ascorbic acid is poorly absorbed when taking contraceptives simultaneously. Vitamin C can be taken with antipsychotics and antidepressants. When treating with antacids, it must be remembered that ascorbic acid promotes the absorption of aluminum in the intestine.
Storage conditions and periods
The drug must be kept exclusively in its original packaging to avoid direct and unwanted contact with air. The temperature regime, which does not spoil the composition of the medicine, should not go beyond +25 ° C. The first aid kit should be hidden away from children.
Each release form has its own expiration date. For dragees - this is 1.5 months, for tablets and powder - 3 years, ampoules - only 12 months.
Conditions for dispensing from pharmacies
You do not need a prescription from a doctor to purchase vitamin C. The most common dosage form is tablets. Ascorbic acid is even sold in supermarkets. As a rule, these are sweet dragees for children in original packaging, similar to candy.
Ascorbic acid: analogues
There are a lot of similar drugs on the pharmaceutical market. Most often people search for “Asvitol”, vitamin C, “Upsavit”, “Ascovit” or “Cevicap”. Prices vary, but do not exceed a value that will be acceptable to each buyer.